Molecules

Small molecule library synthesis using segmented flow

…, JL Poole, JL Cross, I Akritopoulou-Zanze, SW Djuric

Index: Thompson, Christina M.; Poole, Jennifer L.; Cross, Jeffrey L.; Akritopoulou-Zanze, Irini; Djuric, Stevan W. Molecules, 2011 , vol. 16, # 11 p. 9161 - 9177

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Citation Number: 18

Abstract

Abstract Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was ...