Antimalarials. 1. Heterocyclic analogs of N-substituted naphthalenebisoxazines

GS Bajwa, KE Hartman, MM Joullie

Index: Bajwa,G.S. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 134 - 138

Full Text: HTML

Citation Number: 16

Abstract

The principal aim of this investigation was the discovery of new antimalarials. Our approach involved the introduction of various structural changes in compounds which had previously displayed some antimalarial activity. In 1957, Duffm and Rollo synthesized a series of monohydroxyand dihydroxy-substituted naphthalenes by the acidcatalyzed hydrolysis of the corresponding mono-or bisoxazines. Among these compounds, 1, 6-dihydroxy-2, 5-bis ( ...