Enantioselective hydrogenation of pyrrolidine-2, 3, 5-triones over the Pt–cinchonidine system
A Szabo, N Künzle, T Mallat, A Baiker
Index: Szabo; Kuenzle; Mallat; Baiker Tetrahedron Asymmetry, 1999 , vol. 10, # 1 p. 61 - 76
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Citation Number: 45
Abstract
1-and 4-Substituted pyrrolidine-2, 3, 5-triones 5, 6 and 9 have been synthesized and hydrogenated to 3-hydroxy derivatives 10–12 with 17–91% ee using a 5 wt% Pt/Al2O3 catalyst in the presence of small amounts of cinchonidine. The influence of substituents on the enantioselectivity is discussed.
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