Palladium??Catalyzed Coupling of Aldehyde??Derived Hydrazones: Practical Synthesis of Triazolopyridines and Related Heterocycles

OR Thiel, MM Achmatowicz, A Reichelt…

Index: Thiel, Oliver R.; Achmatowicz, Michal M.; Reichelt, Andreas; Larsen, Robert D. Angewandte Chemie - International Edition, 2010 , vol. 49, # 45 p. 8395 - 8398

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Citation Number: 33

Abstract

Triazolopyridines constitute an important class of heteroaromatic compounds. The[1, 2, 4] triazolo [4, 3-a] pyridine moiety [1] can be found in a variety of biologically active compounds, including antibacterial, antithrombotic, antiinflammatory, antiproliferative, and herbicidal agents.[2] To access this class of compounds we became interested in the palladium-catalyzed coupling reactions of 2-chloropyridines with hydrazine derivatives ...

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