Nucleic acid related compounds. 114. Synthesis of 2, 6-(disubstituted) purine 2', 3'-dideoxynucleosides and selected cytotoxic, anti-hepatitis B, and adenosine …

MJ Robins, JS Wilson, D Madej, DLJ Tyrrell…

Index: Robins, Morris J.; Wilson, John S.; Madej, Danuta; Tyrrell, D. Lorne J.; Gati, Wendy P.; Lindmark; Wnuk, Stanislaw F. Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 6 p. 1297 - 1306

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Citation Number: 9

Abstract

The first 2', 3'-dideoxynucleoside, 3'-deoxythymidine, was reported by Michelson and Todd in 1955 [1]. The first purine dideoxynucleoside, 2', 3'-dideoxyadenosine, was reported by Robins and Robins in 1964, who noted that such analogues might function as terminators of nucleic acid biosynthesis if converted into 5'-phosphates and incorporated onto growing DNA chains [2]. This concept, demonstrated independently by Cohen [3] and Kornberg [4] ...