Journal of Fluorine Chemistry

Short synthesis of 4-chloro-4′-(chlorodifluoromethoxy) benzophenone

F Karrer, H Meier, A Pascual

Index: Karrer, Friedrich; Meier, Hans; Pascual, Alfons Journal of Fluorine Chemistry, 2000 , vol. 103, # 1 p. 81 - 84

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Citation Number: 32

Abstract

A one-pot, highly selective synthesis of 4-chloro-4′-(chlorodifluoromethoxy) benzophenone suitable for an industrial scale-up was developed. Fluorination of 4-(trichloromethoxy) benzoyl chloride at–20° C with HF to 4-(chlorodifluoromethoxy) benzoyl fluoride followed by an in situ Friedel–Crafts reaction with chlorobenzene in the presence of BF3 at–5° C yielded the title compound in excellent yield.