New nonsteroidal antiinflammatory agent. 3. Analogs of 2-substituted 5-benzothiazoleacetic acids and their derivatives

H Miyamatsu, S Ueno, M Shimizu…

Index: Miyamatsu,H. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 491 - 496

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Citation Number: 22

Abstract

Compounds of 5-benzothiazole-a-alkylacetic acid with substitutions at the 2 position and/or the alkyl function were synthesized and their pharmacological activities studied. Introduction of a methyl group a to the acetic acid function of 2-phenyl-5-benzothiazoleacetic acid lowered toxicity and enhanced antiinflammatory activity relative to that of phenylbutazone employed as a standard.