Chemical and pharmaceutical bulletin

Biomimetic oxidation of 2-methylimidazole derivative with a chemical model system for cytochrome P-450.

H Miyachi, Y Nagatsu

Index: Miyachi, Hiroyuki; Nagatsu, Yoshio Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 8 p. 1137 - 1140

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Citation Number: 5

Abstract

A chemical model system for cytochrome P-450, consisting of tetraphenylporphyrin manganese chloride (TPPMnCl) and iodosylbenzene, efficiently oxidized 2-methylimidazole to 2-methylimidazolone. This system was next applied to 4-(2-methyl-1-imidazolyl)-2, 2- diphenylbutyramide, a muscarinic acetylcholine receptor antagonist under clinical trial, affording the previously unisolated imidazole ring 5-mono-oxidized derivative that is ...