Solid phase synthesis of a 1, 3, 5-trisubstituted pyridinium salt library

MA Lago, TT Nguyen, P Bhatnagar

Index: Lago, M. Amparo; Nguyen, Thomas T.; Bhatnagar, Pradip Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3885 - 3888

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Citation Number: 23

Abstract

The synthesis of a 1, 3, 5-trisubstituted pyridinium salt combinatorial array containing two variable groups was accomplished in good yields. This entailed the incorporation of 5- bromonicotinic acid onto the resin, followed by Pd (0) catalyzed Suzuki coupling, then alkylation of the pyridine nitrogen and finally cleavage from the resin. A mix and split scheme was also carried out.