An efficient route to 4-(substituted benzyl) piperidines

B Furman, M Dziedzic

Index: Furman, Bartlomiej; Dziedzic, Magdalena Tetrahedron Letters, 2003 , vol. 44, # 45 p. 8249 - 8252

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Citation Number: 16

Abstract

A novel approach to 4-(substituted benzyl) piperidines has been developed. The key steps involve the cyclization of imines bearing an allylsilane in the side-chain followed by the palladium-catalyzed cross-coupling of the resulting 4-methylenepiperidine with organoboronic acids under an atmosphere of oxygen.