Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism

C Yuan, Y Liang, T Hernandez, A Berriochoa, KN Houk…

Index: Yuan, Changxia; Liang, Yong; Hernandez, Taylor; Berriochoa, Adrian; Houk, Kendall N.; Siegel, Dionicio Nature, 2013 , vol. 499, # 7457 p. 192 - 196

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Citation Number: 45

Abstract

Methods for carbon–hydrogen (C–H) bond oxidation have a fundamental role in synthetic organic chemistry, providing functionality that is required in the final target molecule or facilitating subsequent chemical transformations. Several approaches to oxidizing aliphatic C–H bonds have been described, drastically simplifying the synthesis of complex molecules 1, 2, 3, 4, 5, 6. However, the selective oxidation of aromatic C–H bonds under mild ...