Journal of medicinal chemistry

Chemical basis for the biological activity of imexon and related cyanoaziridines

BS Iyengar, RT Dorr, WA Remers

Index: Iyengar, Bhashyam S.; Dorr, Robert T.; Remers, William A. Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 218 - 223

Full Text: HTML

Citation Number: 40

Abstract

Chemical aspects of mode of action of imexon and related cyanoaziridines were studied. These compounds do not alkylate DNA nor react with the ε-amino groups of l-lysine, despite the presence of an aziridine ring. They do react readily with biologically important sulfhydryl compounds to give products derived from either aziridine ring opening, interaction with the cyano group of cyanoaziridines, or opening of the iminopyrrolidone ring of imexon. The ...