Synthesis and characterization of BODIPY-α-tocopherol: a fluorescent form of vitamin E

R West, C Panagabko, J Atkinson

Index: West, Ryan; Panagabko, Candace; Atkinson, Jeffrey Journal of Organic Chemistry, 2010 , vol. 75, # 9 p. 2883 - 2892

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Citation Number: 32

Abstract

Fluorescent nitrobenzoxadiazole analogues of α-tocopherol (NBD-α-Tocs; λex= 468 nm, λem= 527 nm) have been made previously to aid study of the intracellular location and transfer of vitamin E. However, these analogues are susceptible to photobleaching while under illumination for confocal microscopy as well as in in vitro FRET transfer assays. Here we report the synthesis of three fluorescent analogues of α-tocopherol incorporating the ...

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