Synthesis of Symmetrical Dinitro??and Diamino??Substituted Tröger's Base Analogues

J Šturala, R Cibulka

Index: Sturala, Jiri; Cibulka, Radek European Journal of Organic Chemistry, 2012 , # 36 p. 7066 - 7074

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Citation Number: 3

Abstract

Abstract This report describes a new synthetic approach to symmetrical diamino-substituted Tröger's base analogues, allowing the synthesis of 1, 7-, and 4, 10-diamino derivatives with no additional substituents and of 3, 9-diamino derivative with methyl groups in the 1-, 4-, 7- and 10-positions. The synthesis uses regioselective nitration of dihalo-substituted-or tetrahalo-substituted Tröger's bases followed either by hydrogenation of the nitro functions ...