Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor

…, MI Colombo, C Wasowski, H Viola, C Wolfman…

Index: Marder, Mariel; Zinczuk, Juan; Colombo, Maria I.; Wasowski, Cristina; Viola, Haydee; Wolfman, Claudia; Medina, Jorge H.; Ruveda, Edmundo A.; Paladini, Alejandro C. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 2003 - 2008

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Citation Number: 40

Abstract

A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already, described, indicates that substitutions at position 6 or 6 and 3'in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.