Facile regiospecific syntheses of N?螃?, N??1 (τ)??dialkyl??l??histidines

SK Nayak, V Monga, N Kaur…

Index: Nayak, Surendra Kumar; Monga, Vikramdeep; Kaur, Navneet; Jain, Rahul Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1265 - 1269

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Abstract

Backbone modification by conformational restriction of amide bond is an attractive strategy to obtain useful information about bioactive conformation of peptides [1, 2]. Such modifications introduce local backbone constraints, eg N-α-alkylation greatly limits the φ torsional angle that restricts the affected residue and the amino acid preceding it to an extended conformation [3], eliminates the potential intramolecular hydrogen bonding ...

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