Pyrazolo [3, 4-d] pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo [3, 4-d] pyrimidines

JL Rideout, TA Krenitsky, GW Koszalka…

Index: Rideout; Krenitsky; Koszalka; Cohn; Chao; Elion; Latter; Williams Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1040 - 1044

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Citation Number: 33

Abstract

(Scheme I, method A). The details of the enzyme-catalyzed synthesis of 1 and 3 are provided under Experimental Section. Preparations of 7 (Scheme I, methods B and C) are also described in detail. A procedure similar to that outlined in method B (Scheme I) has been reported. 6 Method C in Scheme I was based on the work of Vorbruggen and Kroliewiez6 with purine ribonucleosides. Compound 7 was prepared by methods B and C. ...