A simple and practical method for large-scale acetylation of alcohols and diols using bismuth triflate

MD Carrigan, DA Freiberg, RC Smith, HM Zerth…

Index: Carrigan; Freiberg; Smith; Zerth; Mohan Synthesis, 2001 , # 14 p. 2091 - 2094

Full Text: HTML

Citation Number: 46

Abstract

Recently, the use of bismuth triflate as a catalyst for the acylation of alcohols has been reported. [18] In this method, acetylation of alcohols is carried out on a small (1 mmol) scale using a large excess of acetic anhydride as the solvent (ten equivalents). In some cases, a small amount of a co-solvent is also used. However, this communication does not provide a detailed procedure for acetylation and only GC yields are reported for all but one example. In view of ...