Vilsmeier–Haack reaction of tertiary alcohols: formation of functionalised pyridines and naphthyridines

AD Thomas, CV Asokan

Index: Thomas; Asokan Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 20 p. 2583 - 2587

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Abstract

Vilsmeier–Haack reaction of 2-arylpropan-2-ols proceeds with multiple iminoalkylations leading to the formation of conjugated iminium salts which on ammonium acetate-induced cyclisation afford 4-arylnicotinaldehydes in good yields. Tertiary alcohols derived from ...

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