Chemical and pharmaceutical bulletin

Preparation and properties of 3-alkyl-1-arylnitrosoureas and related compounds.

M TANNO, S SUEYOSHI

Index: Tanno, Masayuki; Sueyoshi, Shoko Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 4 p. 1360 - 1371

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Citation Number: 8

Abstract

Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99% formic acid or with isoamyl nitrite in chloroform. The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1- nitrosoureas were isomerized to the 3-nitroso isomers by acids. The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and ...