Synthesis and characterization of novel cycloalkanespiro-5-hydantoin phosphonic acids

ED Naydenova, PT Todorov…

Index: Naydenova, Emilia D.; Todorov, Petar T.; Troev, Kolio D. Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1315 - 1320

Full Text: HTML

Citation Number: 17

Abstract

A series of new cycloalkanespiro-5-hydantoin phosphonic acids have been synthesized and characterized. The mixture of [(2, 4-dioxo-1, 3-diazaspiro-alkane-3-yl)-methyl] phosphonic acids and [(2, 4-dioxo-1, 3-diazaspiro-alkane-1, 3-diyl) dimethyl] diphospho-nic acids was obtained from cycloalkanespiro-5-hydantoins, formaldehyde, and phosphorus trichloride in a molar ratio of 1: 2: 2, by a procedure modified by us. Their structures were proved by ...

Related Articles:

Peptide sweeteners. 6. Structural studies on the C-terminal amino acid of L-aspartyl dipeptide sweeteners

[Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668]

Aminoderivatives of cycloalkanespirohydantoins: synthesis and biological activity

[Naydenova, Emilia; Pencheva, Nevena; Popova, Julita; Stoyanov, Neyko; Lazarova, Maria; Aleksiev, Boris Farmaco, 2002 , vol. 57, # 3 p. 189 - 194]

More Articles...