Anti-hypertensives: 1-alkyl-2-arylpiperazinoethyl-1H-naphth [1, 2-d] imidazoles

…, G Di Francesco, D Barone, E Baldoli, N Corsico…

Index: Toja, Emilio; Francesco, Giuseppe Di; Barone, Domenico; Baldoli, Emiliana; Corsico. Nerina; Tarzia, Giorgio European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 221 - 228

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Citation Number: 6

Abstract

Abstract L 15848 (8b citrate) is a new anti-hypertensive agent belonging to the class of 1- alkyl-2-aminoethylnaphth-[1, 2-d] imidazoles. It lowers blood pressure in spontaneously hypertensive rats (50 mg/kg, po) and in conscious normotensive and renal hypertensive dogs (5–20 mg/kg, po). The decrease in systolic blood pressure is dose related and long lasting, and is evident for periods of up to 7 h. A slight and transient decrease in heart rate ...