Antifibrinolytic activity of nicotinic acid conjugates with 6-aminohexanoic, p-aminomethylbenzoic, and trans-4-aminomethylcyclohexanecarboxylic acids

…, AG Moiseenok, LN Bulanova, VM Kopelevich…

Index: Zabelin, N. N.; Moiseenok, A. G.; Bulanova, L. N.; Kopelevich, V. M.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 5 p. 334 - 338 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 5 p. 562 - 566

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Abstract

N-(Nicotinoyl)-6-aminohexanoic Acid (IV). A lg portion of nicotinic ch! oroanhydride chlorohydrate was added in small doses to a solution of 0.96 g of 6-aminchexanoic acid and 0.74 g of NaOH in i0 ml of water at 0-5~ After the entire! g was added, the mixture was allowed to air-warm, with stirring, to 20~ after which 20 ml of water were added. The mixture was then acidified with concentrated HCI to pH 3.0-3.5. The resultant precipitate was ...