Structure-activity relationships of a series of pyrrolo [3, 2-d] pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

…, N Chen, Z Chen, C Fotsch, C Hale…

Index: Brown, Pamela; Calvert, Stephen H.; Chapman, Pauline C. A.; Cosham, Suzanne C.; Eglington, A. John; et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 4 p. 881 - 891

Full Text: HTML

Citation Number: 129

Abstract

... of Small Molecule Drug Discovery and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789. ... or 2° amines (R 3 = NR 2 ), K 2 CO 3 , H 2 O; (h) R 3 B ... CH 2 Cl 2 ; (b) bis(pinacolato)diboron, PdCl 2 (dppf), KOAc, DMSO, 70 °C; (c) 14 (where ...