Synthesis and biological evaluation of some innovative coumarin derivatives containing thiazolidin-4-one ring

CK RamaGanesh, YD Bodke…

Index: RamaGanesh; Bodke, Yadav D.; Venkatesh Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 8 p. 1151 - 1154

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Citation Number: 15

Abstract

Abstract: The reaction of ethyl 2-oxo-2H-chromene-3-carboxylate with hydrazine followed by condensation of the resulting hydrazone with different aromatic aldehydes give the corresponding Schiff bases 5a-e. Reaction of these Schiff bases with mercaptoacetic acid furnishes the target thiazolidinone molecules 6a-e. The newly synthesized compounds have been screened for antibacterial and analgesic activities.