Reaction of 3??hydroxy??1, 2, 3, 4??tetrahydroquinoline??2, 4??diones with ethyl (triphenylphosphoranylidene) acetate

…, M Kovář, A Klásek, T Kappe

Index: Kafka, Stanislav; Kovar, Michal; Klasek, Antonin; Kappe, Thomas Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1977 - 1982

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Citation Number: 13

Abstract

Abstract The Wittig reaction of 3-hydroxy-1, 2, 3, 4-tetrahydroquinoline-2, 4-diones 2 with ethyl (triphenyl-phosphoranylidene) acetate 3 proceeds stereoselectively to give E-4- carbethoxymethylene-1, 2, 3, 4-tetra-hydro-2-quinolones 4, which were hydrolyzed to corresponding acids 6 Butenolides 5 were detected and, in some cases, isolated as a minor product of the Wittig reaction.

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