Discovery of EGFR selective 4, 6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library

Q Zhang, Y Liu, F Gao, Q Ding, C Cho…

Index: Journal of the American Chemical Society, , vol. 128, # 7 p. 2182 - 2183

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Citation Number: 47

Abstract

... 4 Curiously, despite years of intensive research on EGFR inhibitors, there is a surprising dearth of chemically distinct small molecule inhibitors with a high degree of selectivity. ... Journal of the American Chemical Society (2002), 124 (8), 1594-1596CODEN: JACSAT ; ISSN ...