Microwave??Assisted Synthesis of 2??Amino??thiophene??3??Carboxylic Derivatives Under Solvent??Free Conditions

W Huang, J Li, J Tang, H Liu, J Shen…

Index: Huang, Wei; Li, Jian; Tang, Jing; Liu, Hong; Shen, Jianhua; Jiang, Hualiang Synthetic Communications, 2005 , vol. 35, # 10 p. 1351 - 1357

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Citation Number: 36

Abstract

Abstract Under microwave irradiation and solvent??free conditions, cyanoacetates (cyanoacetamides) react with ketones and sulphur in the presence of a small amount of morpholine to give 2??amino??thiophene??3??carboxylic derivatives. In particular, tetrahydro?? benzo [b] thiophene??3??carboxylic acid N??aryl amides were synthesized in high yields of 84– 95%.