Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl) methanol (NSC23925) isomers to reverse multidrug resistance in cancer

…, E Choy, D Harmon, H Mankin, F Hornicek

Index: Duan, Zhenfeng; Li, Xin; Huang, Haoxi; Yuan, Wei; Zheng, Shao-Liang; Liu, Xianzhe; Zhang, Zhan; Choy, Edwin; Harmon, David; Mankin, Henry; Hornicek, Francis Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3113 - 3121

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Citation Number: 21

Abstract

Development of multidrug resistance (MDR) during chemotherapy is a fundamental obstacle associated with cancer care. Prior studies have identified (2-(4-methoxyphenyl)-4- quinolinyl)(2-piperidinyl) methanol (5)(NSC23925) to be a small molecule agent that reverses MDR in cancer cells. We synthesized all four isomers of 5 and analyzed them by liquid chromatography–mass spectrometry (LCMS). Structure–activity relationships for ...