Hydrophilic 1-(carboxymethyl)-5-fluorouracil amides: Preparation and cytostatic activity

H Pischel, A Holý, J Veselý, G Wagner…

Index: Pischel, Helmut; Holy, Antonin; Vesely, Jiri; Wagner, Guenther; Cech, Dieter Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2061 - 2069

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Citation Number: 2

Abstract

Abstract The following N-substituted amides IV were prepared by reaction of 1- (carboxymethyl)-5-fluorouracil p-nitrophenyl ester (II) with primary or secondary hydroxyalkylamines III: 2-hydroxypropyl (IVa), 3-hydroxypropyl (IVb), 2, 3-dihydroxypropyl (IVc), 3-hydroxy-2-methyl-2-propyl (IVd), 1, 3-dihydroxy-2-propyl (IVe), 1-deoxyglucitol-1-yl (IVg), 2-deoxyglucitol-2-yl (IVh), methyl-2, 3-dihydroxypropyl (IVi), methyl-1-deoxyglucitol- ...