Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality

P Besada, L Mamedova, CJ Thomas…

Index: Besada, Pedro; Mamedova, Liaman; Thomas, Craig J.; Costanzi, Stefano; Jacobson, Kenneth A. Organic and Biomolecular Chemistry, 2005 , vol. 3, # 10 p. 2016 - 2025

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Citation Number: 35

Abstract

Diketopiperazines (DKPs) are a common motif in various biologically active natural products, and hence they may be useful scaffolds for the rational design of receptor probes and therapeutic agents. We constructed a new bicyclic scaffold that combines a DKP bridged with a 10-membered ring. In this way we obtained a three-dimensional molecular skeleton, with several amendable sites that provide a starting point to design a new ...

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