Tetrahedron Letters

A scalable approach to diaminopyrazoles using flow chemistry

NS Wilson, AT Osuma, JA Van Camp, X Xu

Index: Wilson, Noel S.; Osuma, Augustine T.; Camp, Jennifer A.Van; Xu, Xiangdong Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4498 - 4501

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Citation Number: 11

Abstract

This Letter reports on how the combination of microwave and continuous flow chemistry facilitated the convenient preparation of aminopyrazoles from commercial aryl halides. The method was applied to a variety of substrates with good to excellent yields and further extended toward the complete flow synthesis of 5, 7-dimethyl-3-phenylpyrazolo [1, 5-a] pyrimidin-2-amine.

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