Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays
C Garino, T Tomita, N Pietrancosta…
Index: Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4275 - 4285
Full Text: HTML
Citation Number: 57
Abstract
... Journal of Medicinal Chemistry. ... Introduction. As the number of cases of Alzheimer's disease (AD) rises in developed countries, the unmet medical need for disease-modifying pharmacotherapy continues to grow. Much ...
Related Articles:
[Garino, Cedrik; Tomita, Taisuke; Pietrancosta, Nicolas; Laras, Younes; Rosas, Roselyne; Herbette, Gaetan; Maigret, Bernard; Quelever, Gilles; Iwatsubo, Takeshi; Kraus, Jean-Louis Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4275 - 4285]