Synthesis of diastereomeric ketoconazole analogs

DR Chapman, L Bauer, DP Waller…

Index: Chapman; Bauer; Waller; Zaneveld Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068

Full Text: HTML

Citation Number: 9

Abstract

Abstract Syntheses of trans-isomers of ketoconazole, and the corresponding des-acetyl, 1- methyl-, 1-formyl and 1-methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis-diastereomers were characterized by their carbon-13 nmr spectra.