The Journal of organic chemistry

A modular and concise total synthesis of (±)-Daurichromenic acid and analogues

H Hu, TJ Harrison, PD Wilson

Index: Hu, Hongjuan; Harrison, Tyler J.; Wilson, Peter D. Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3782 - 3786

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Citation Number: 61

Abstract

A modular and concise total synthesis of (±)-daurichromenic acid has been accomplished in four steps from ethyl acetoacetate, ethyl crotonate, and trans, trans-farnesal. A series of analogues of this natural product, which has potent anti-HIV activity, were also prepared from ethyl or methyl acetoacetate and a series of readily available α, β-unsaturated esters and aldehydes.