Synthesis of antihyperglycemic, α-glucosidase inhibitory, and DPPH free radical scavenging furanochalcones

…, KS Babu, G Suresh, AZ Ali, K Madhusudana…

Index: Rao, R. Ranga; Tiwari, Ashok K.; Reddy, P. Prabhakar; Babu, K. Suresh; Suresh; Ali, A. Zehra; Madhusudana; Agawane, Sachin B.; Badrinarayan, Preethi; Sastry, G. Narahari; Rao, J. Madhusudana Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 760 - 774

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Citation Number: 18

Abstract

Abstract A series of furanochalcone derivatives have been designed and synthesized. Molecular modeling studies were carried out to probe into the mechanism of binding of chalcone inhibitors and understand the structure–activity relationship to identify the contribution of scaffolds and groups in the synthesized analogs to biological activity. The three-dimensional model of α-glucosidase was constructed based on the crystal structure ...