Enantioselective direct intermolecular aldol reactions with enantiotopic group selectivity and dynamic kinetic resolution

DE Ward, V Jheengut, OT Akinnusi

Index: Agami, Claude; Platzer, Nicole; Sevestre, Hubert Bulletin de la Societe Chimique de France, 1987 , # 2 p. 358 - 360

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Citation Number: 69

Abstract

... 14. We have been developing stereoselective sequential two-directional aldol reactions of 9 and 10 as the foundation of a thiopyran-based synthetic route to ... Scheme 2. ... is re-isolated in >85% yield and >90% ee after exposure to (S)- or (R)-proline (48 h, wet DMSO); (ii) racemic 9 ...