Protein kinase affinity reagents based on a 5-aminoindazole scaffold

R Krishnamurty, AM Brock, DJ Maly

Index: Krishnamurty, Ratika; Brock, Amanda M.; Maly, Dustin J. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 550 - 554

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Citation Number: 5

Abstract

Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures.