Process improvements in the synthesis of corticosteroid 9, 11β-epoxides

X Fu, CH Tann, TK Thiruvengadam

Index: Organic Process Research and Development, , vol. 5, # 4 p. 376 - 382

Full Text: HTML

Citation Number: 6

Abstract

... Organic Process Research & Development. ... give rise to an impurity such as 11 via 19 at a level that is not purgable by the existing purification procedure. ... has been developed for the synthesis of β-epoxide 3 based on systematic studies of the deficiencies of the existing process. ...