Tetrahedron

Synthesis of novel α-amino-acids and derivatives using radical chemistry: synthesis of L-and D-α-amino-adipic acids, L-α

DHR Barton, Y Hervé, P Potier, J Thierry

Index: Barton; Herve; Potier; Thierry Tetrahedron, 1987 , vol. 43, # 19 p. 4297 - 4308

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Citation Number: 95

Abstract

Radicals generated by photolysis (W light) of suitably protected amino-acid derivatives of N- hydroxy-2-thiopyridone add efficiently to activated olefins to afford satisfactory yields of adducts. Oxidation of the thiopyridyl residue to sulphoxide and thermal elimination afford excellent yields of the corresponding α, β-unsaturated derivatives. Lateral chain decarboxylation of suitably protected aspartic and glutamic acids provides convenient ...

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