Application of the Lewis Acid-Lewis Base Bifunctional Asymmetric Catalysts to Pharmaceutical Syntheses: Stereoselective Chiral Building Block Syntheses of Human …

H Nogami, M Kanai, M Shibasaki

Index: Nogami, Hiroyuki; Kanai, Motomu; Shibasaki, Masakatsu Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 702 - 709

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Citation Number: 25

Abstract

Chiral building block syntheses of promising drugs were achieved using two types of catalytic stereoselective cyanosilylations of aldehydes promoted by Lewis acid–Lewis base bifunctional catalysts 1 and 2 as the key steps (diastereoselective cyanosilylation of amino aldehyde and enantioselective cyanosilylation). In the first part of this article, syntheses of chiral building blocks (6) of Atazanavir (3: human immunodeficiency virus (HIV) protease ...