Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram: A Key Intermediate for Escitalopram#

CR Elati, N Kolla, PJ Vankawala…

Index: Organic Process Research and Development, , vol. 11, # 2 p. 289 - 292

Full Text: HTML

Citation Number: 18

Abstract

... Organic Process Research & Development. ... of citalopram (1a), initially we focused on development of a diastereomeric salt resolution process for 1a. ... After several unsuccessful synthetic approaches we established an optimum procedure to access (±)-(4) by C-alkylation of 1-(4 ...

Related Articles:

Response to the Comments by Elati et al. in Response to Our Article Examining One of Their Previous Articles

[Organic Process Research and Development, , vol. 13, # 1 p. 38 - 43]

Enzymatic resolution of a quaternary stereogenic centre as the key step in the synthesis of (S)-(+)-citalopram

[Tetrahedron Asymmetry, , vol. 15, # 2 p. 341 - 345]

More Articles...