Design, synthesis, and evaluation of linker-duocarmycin payloads: Toward selection of Her2-targeting antibody–drug conjugate SYD985

RC Elgersma, RGE Coumans, T Huijbregts…

Index: Dubowchik, Gene M.; Firestone, Raymond A. Bioorganic & Medicinal Chemistry Letters, 1998 , vol. 8, # 23 p. 3343 - 3346

Full Text: HTML

Citation Number: 20

Abstract

... Departments of † Medicinal & Protein Chemistry, ‡ Preclinical, and § New Molecular Entities ... Both are tubulin polymerization inhibitors that bind to the vinca domain in tubulin and that cause cell cycle arrest in the G2-M phase, eventually leading to apoptotic cell death. ...