Copper (I)??Catalyzed Decarboxylative Coupling of Propiolic Acids with Secondary Amines and Aldehydes

DS Ermolat'ev, H Feng, G Song…

Index: Feng, Huangdi; Ermolat'Ev, Denis S.; Song, Gonghua; Van Der Eycken, Erik V Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7608 - 7613

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Citation Number: 5

Abstract

Abstract An efficient microwave-assisted synthesis of tertiary propargylamines has been developed by copper (I)-catalyzed decarboxylative A 3-coupling reaction of an alkynylcarboxylic acid with a secondary amine and an aldehyde. A wide range of diversely substituted propargylamines could be synthesized in high yields. The optimal reaction conditions are also effective for 3-alkylpropiolic acids and for terminal propiolic acid.