Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents
…, X Nan, J Tian, SL Morris-Natschke, ZJ Zhang…
Index: Liu, Ying-Qian; Li, Xiao-Jing; Zhao, Chun-Yan; Nan, Xiang; Tian, Jing; Morris-Natschke, Susan L.; Zhang, Zhi-Jun; Yang, Xiao-Ming; Yang, Liu; Li, Lin-Hai; Zhou, Xing-Wen; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1248 - 1256
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Citation Number: 9
Abstract
Two series (14a–d and 21a–h) of novel spin-labeled combretastatin derivatives were synthesized and evaluated for cytotoxicity against four tumor cell lines (K562, SGC-7901, Hela and HepG-2). Simultaneously, a representative compound 21a was selected to investigate the antitumor mechanisms of these synthetic compounds. The results indicated that some of the compounds showed significant cytotoxicity against four tumor cell lines in ...
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