The Journal of Organic Chemistry

Asymmetric synthesis of. alpha.-alkyl-. alpha. amino acids from chromium-carbene-complex-derived. beta.-lactams

PJ Colson, LS Hegedus

Index: Colson, Pierre-Jean; Hegedus, Louis S. Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 5918 - 5924

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Citation Number: 109

Abstract

Introduction a-Alkyl-a-amino acids constitute an important class of nonproteinogenic amino acids which has received a great deal of recent attenti0n. l Incorporation of these compounds into peptides results in conformational restrictions and increased rigidity, leading to enhanced resistance toward protease enzymes? and to the favoring of particular secondary structure^.^ In addition, the compounds themselves may act as enzyme ...

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