Multivalent, high-relaxivity MRI contrast agents using rigid cysteine-reactive gadolinium complexes

…, DW Romanini, KN Raymond, MB Francis

Index: Garimella, Praveena D.; Datta, Ankona; Romanini, Dante W.; Raymond, Kenneth N.; Francis, Matthew B. Journal of the American Chemical Society, 2011 , vol. 133, # 37 p. 14704 - 14709

Full Text: HTML

Citation Number: 69

Abstract

MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium (III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to ...

Related Articles:

An efficient chemoenzymatic method to prepare optically active primary–tertiary trans-cycloalkane-1, 2-diamines

[Quijada, F. Javier; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente Tetrahedron, 2009 , vol. 65, # 38 p. 8028 - 8034]

Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists

[Journal of Medicinal Chemistry, , vol. 51, # 4 p. 721 - 724]

More Articles...