Synthetic and biotransformation studies on prochiral non??proteinogenic amino acids: diethyl α??acetamido, α??alkylmalonates

…, W Errington, YN Belokon, KA Kochetkov…

Index: Singh; Prasad; Errington; Belokon; Kochetkov; Saxena; Jain; Parmar Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 1 p. 10 - 15

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Citation Number: 3

Abstract

Abstract: Nine diethyl α-acetamido, α-alkylmalonates 3-11 (alkyl= methyl, benzyl, 3- fluorobenzyl, 4-fluorobenzyl, 2, 6-difluorobenzyl, 3-trifluoromethylbenzyl, 4- trifluoromethylbenzyl, 2-chlorobenzyl and 3-chlorobenzyl) have been synthesised in three steps starting with diethyl malonate in overall yields of 49-90%. The structures of C-alkylated acetamidomalonates have been established on the basis of their spectral data, the ...