Preparation of 2 (R) and 2 (S) methyl-2-methylglycerates

JB Rodríguez, SP Markey, H Ziffer

Index: Rodriguez, Juan B.; Markey, Sanford P.; Ziffer, Herman Tetrahedron: Asymmetry, 1993 , vol. 4, # 1 p. 101 - 108

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Citation Number: 4

Abstract

Abstract Optically pure samples of both enantiomers of methyl 2, 3-dihydroxy-2- methylpropanoate were prepared by a chromatographic separation of their (−)-menthyl esters followed by hydrolysis and methylation. Their absolute stereochemistries were established by conversion into their 3-O-acetyl derivatives, compounds of established configuration. NMR and CG-MS methods of determining the optical purities of the diols are ...