Tetrahedron Letters

A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry

L Li, B Lin, Z Yang, L Zhang, L Zhang

Index: Li, Lingjun; Lin, Baichuan; Yang, Zhenjun; Zhang, Liangren; Zhang, Lihe Tetrahedron Letters, 2008 , vol. 49, # 29-30 p. 4491 - 4493

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Citation Number: 27

Abstract

Novel nucleobase-modified cADPR mimics were synthesized by the application of click chemistry. Cu (I)-Huisgen cycloaddition (click reaction) was used to construct 4-amide-1, 2, 3- triazole nucleobase and connect two building blocks efficiently. A concise protection strategy was used for the synthesis of the corresponding cyclo-pyrophosphate, and the target compounds 6a and 6b were prepared within four steps.

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